Junior / Senior level Not enough experience

You didn’t mention your specific tenure at the startup. If you had a few years in then you should hopefully have enough portfolio of work that talks to your experience. In ID people usually are less worried about your very specific skillsets in a junior or mid level role, they want to see you have the skill set and process to adapt.

If you are applying to jobs that really want someone who can drop in and slot right into a position at a more senior level, they may want someone who has more experience in a certain field.

My biggest suggestion would be to post your portfolio and ask for feedback. If you are missing certain skills in key areas you can use the time off to work on those.