Have to call this one out (and many in the Nerdist fold) as it was my ‘first’.
Besides many listed above I’ll add
-StarTalk - Neil deGrasse Tyson’s one
More than podcasts, last year I’ve subscribed to many YouTube channels, a few have fallen to the wayside, but there’s still is a bunch I listen to/watch daily. Some of them are basically conversations, so I’ll listen to them like a podcast as I work.