I just did the going-back-to-a-small-town move after a year and a half in a job where the geography and culture we’re burning me out. It was a good move. After a few months of sabbatical, I got a job with a company in the closest “big city”. For me, I was only a 30 minute drive from the bigger city, so it really had no impact on my job hunt.
I’d guess that you’ll be ok if you can make it to interviews.
If you’re looking for remote or freelance work, I’d think it would be tough because most of that stuff seems to come out of networking.