If you aren’t overclocking, the OEM CPU cooler is fine. If you want burly or quiet, you can go with a canned watercooler like a Corsair H60 or a Coolermaster Hyper 212 which is plenty of bang for the buck even when overclocking.
I’d go with the GTX760 unless you do a lot of GPU heavy work. If you find it’s too slow you can upgrade it, but the 780 will be overkill for most CAD applications. The Quadro will give you some higher end features in certain tools, but you may not need it. Most people CAD on gaming cards these days.
For a power supply I’d go with something like a 600+ watt modular PSU just so you have room to scale. Modular just makes it easier to use only the cables you need.
Make sure to get a good SSD and nice monitor and you’ll be all set. If you post your build I can provide more specifics but you should be able to build a nice 4770k system for under $1500 and still have $2k left over for monitors and a Macbook air.