I would agree that grades mean almost nothing. If your portfolio is solid I could care less that your GPA was brought down by a poor performance in your psychology class.
I actually was given some very mediocre grades in school, and in speaking to my professors after graduation they pointed out they gave me grades lower than my classmates not because my work was worse, but because they saw that I was not working up to my full potential, whereas students who got “A” work were as good as they saw they were going to get. After being mad as heck at the time I realized after graduation that C pushed me harder than ever to improve myself. It certainly didn’t help my GPA, but it absolutely pushed me to develop my portfolio. That alone makes me disregard anything about “GPA” on a CV.