For travel, I got one from REI (discontinued) that I love because it’s got three full length compartments, with the padded lappy in the back. The middle compartment is a good 6" deep, so I can throw my SLR camera bag in there. And theres a nice outer pocket for magazines, power adapters etc. Not great looking, but ideal functionality.
This comes close: http://www.rei.com/product/769840
For the office, I use a Tumi Formula T Circuit: