-Rhino for 3D Work ( If I could afford/justify the expense solidworks /keyshot)
-Manga Studio for Digital Sketching, 2D illustrations and UI UX mockups ( it mostly has replaced sketchbook/Illustrator/Photoshop)
-Photoshop for Images,final comps,etc.
Not directly design..
When doing software/web work all I have open for weeks on end is Atom.
When writing/researching Scrivener.
When doing project planning Excel.